The recent availability of transgenic mouse models of Alzheimer disease has allowed direct
in vivo assessment of the molecular and neuropathological effects of cerebral amyloid …

Transgenic mice carrying disease-linked forms of genes associated with Alzheimer disease
often demonstrate deposition of the β-amyloid as senile plaques and cerebral amyloid …

The main objective of the present study was to develop an alternative singly‐transgenic (tg)
hAPP model where amyloid deposition will occur at an earlier age. For this purpose, we …

In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …

Amyloid deposition appears to be an early and crucial event in Alzheimer's disease (AD). To
generate animal models of AD, mice expressing full-length amyloid precursor protein (APP) …

The PDAPP transgenic mouse overexpresses human amyloid precursor protein V717F
(PDAPP minigene) and develops age-related cerebral amyloid-β protein (Aβ) deposits …

Alzheimer's disease (AD) pathology is characterized by Aβ peptide‐containing plaques,
neurofibrillary tangles consisting of hyperphosphorylated tau, extensive neuritic …

According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary
driving force in Alzheimer's disease pathogenesis. Despite the development of many …

Transgenic (Tg) mice that overexpress mutant familial Alzheimer's disease (AD) amyloid
precursor protein (APP) genes have contributed to an understanding of dementia pathology …

Alzheimer's disease is the most widespread form of dementia. Its histopathological
hallmarks include vascular and extracellular β-amyloid (Aβ) deposition and intraneuronal …