In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …

In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe
interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular …

Periostin is overexpressed in autosomal dominant polycystic kidney disease (ADPKD) and
in mice with polycystic kidney disease (PKD). Darren Wallace and colleagues at the …

Periostin is a matricellular protein that is expressed in several tissues during embryonic
development; however, its expression in adults is mostly restricted to collagen-rich …

Progressive renal enlargement due to the growth of innumerable fluid-filled cysts is a central
pathophysiological feature of autosomal dominant polycystic kidney disease (ADPKD) …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …

Background: Periostin is responsible for tissue regeneration, fibrosis, and wound healing via
its interaction with integrin. Recently, the role of periostin has been shown to contribute to …

The matrix metalloproteinase MMP9 influences cellular morphology and function, and plays
important roles in organogenesis and disease. It exerts both protective and deleterious …

Matricellular proteins participate in the pathogenesis of chronic kidney diseases. We
analyzed glomerular gene expression profiles from patients with proteinuric diseases to …

Increased renal expression of periostin, a protein normally involved in embryonic and dental
development, correlates with the decline of renal function in experimental models and …