Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1
In mammals, DNA methylation is crucial for embryonic development and germ cell
differentiation. The DNA methylation patterns are created by de novo-type DNA …
differentiation. The DNA methylation patterns are created by de novo-type DNA …
Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA
H Takeshima, I Suetake, H Shimahara… - Journal of …, 2006 - academic.oup.com
In mammals, the resetting of DNA methylation patterns in early embryos and germ cells is
crucial for development. De novo type DNA methyltransferases Dnmt3a and Dnmt3b are …
crucial for development. De novo type DNA methyltransferases Dnmt3a and Dnmt3b are …
DNA methyltransferase 3b preferentially associates with condensed chromatin
K Kashiwagi, K Nimura, K Ura… - Nucleic acids research, 2011 - academic.oup.com
In mammals, DNA methylation is catalyzed by DNA methyltransferases (DNMTs) encoded
by Dnmt1, Dnmt3a and Dnmt3b. Since, the mechanisms of regulation of Dnmts are still …
by Dnmt1, Dnmt3a and Dnmt3b. Since, the mechanisms of regulation of Dnmts are still …
A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
Dnmt3a and Dnmt3b are paralogous enzymes responsible for de novo DNA methylation but
with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes …
with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes …
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases
H Gowher, CJ Stockdale, R Goyal, H Ferreira… - Biochemistry, 2005 - ACS Publications
In the cell, DNA is wrapped on histone octamers, which reduces its accessibility for DNA
interacting enzymes. We investigated de novo methylation of nucleosomal DNA in vitro and …
interacting enzymes. We investigated de novo methylation of nucleosomal DNA in vitro and …
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation
DNA methylation is involved in fundamental cellular processes such as silencing of genes
and transposable elements, but the underlying mechanism of regulation of DNA methylation …
and transposable elements, but the underlying mechanism of regulation of DNA methylation …
[HTML][HTML] p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes
JE Sandoval, NO Reich - Journal of Biological Chemistry, 2021 - ASBMB
DNA methylation and histone tail modifications are interrelated mechanisms involved in a
wide range of biological processes, and disruption of this crosstalk is linked to diseases …
wide range of biological processes, and disruption of this crosstalk is linked to diseases …
The N-terminus of histone H3 is required for de novo DNA methylation in chromatin
DNA methylation and histone modification are two major epigenetic pathways that interplay
to regulate transcriptional activity and other genome functions. Dnmt3L is a regulatory factor …
to regulate transcriptional activity and other genome functions. Dnmt3L is a regulatory factor …
Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro
AK Robertson, TM Geiman, UT Sankpal… - Biochemical and …, 2004 - Elsevier
DNA methylation is an epigenetic modification of the genome critical for numerous
processes, including transcriptional repression and maintenance of chromatin structure …
processes, including transcriptional repression and maintenance of chromatin structure …
[HTML][HTML] Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation
A nucleosome contains two copies of each histone H2A, H2B, H3 and H4. Histone H3
K4me0 and K36me3 are two key chromatin marks for de novo DNA methylation catalyzed by …
K4me0 and K36me3 are two key chromatin marks for de novo DNA methylation catalyzed by …