DNA is methylated at the dinucleotide CpG in genomes of a wide range of plants and
animals. Among animals, variable patterns of genomic CpG methylation have been …

In invertebrates that harbor functional DNA methylation enzymatic machinery, gene-bodies
are the primary targets for CpG methylation. However, virtually all other aspects of …

DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …

Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of
active genes, and the extent of methylation biology conservation is unclear. We quantified …

GC skew is a measure of the strand asymmetry in the distribution of guanines and cytosines.
GC skew favors R-loops, a type of three stranded nucleic acid structures that form upon …

Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic
organisms. Although DNA methylation likely has a conserved role in gene silencing, the …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

Methylation of CpG dinucleotides is a reversible modification of DNA that is highly prevalent
throughout mammalian genomes. Recent advances generated genomic DNA methylation …

DNA methylation is a dynamic process through which specific chromatin modifications can
be stably transmitted from parent to daughter cells. A large body of work has suggested that …

Background Studies of DNA methylomes in a wide range of eukaryotes have revealed both
conserved and divergent characteristics of DNA methylation among phylogenetic groups …