The treatment of neonatal seizures has not changed significantly over the last 50 years
despite advances in antiepileptic drug (AED) development for older children and adults …

Neonatal seizures have unique properties that have proved challenging for both clinicians
and basic science researchers. Clinical therapies aimed at neonatal seizures have proven …

Seizures occur more often during the neonatal period than at any other period of life. Precise
incidence is difficult to delineate and depends on study population and criteria used for …

Neonatal seizures can be classified as tonic, clonic, myoclonic, and subtle. A clinical
diagnosis is not easy as seizures are usually subtle in neonates. In the majority of newborn …

Medically refractory neonatal seizures represent a major therapeutic challenge in neonatal
intensive care units. Conventional antiepileptic drugs demonstrate limited efficacy. Previous …

Seizures are the most common neurological emergencies in the neonatal period and are
associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 …

Pharmacologic treatment options for neonatal seizures have expanded over the past 2
decades, and there is no consensus on optimal treatment strategy. We systematically …

Although seizures have a higher incidence in neonates than any other age group and are
associated with significant mortality and neurodevelopmental disability, treatment is largely …

Aim The existing treatment options for neonatal seizures have expanded over the last few
decades, but no consensus has been reached regarding the optimal therapeutic protocols …

Seizures are the most common neurological emergency in the neonates, and this age group
has the highest incidence of seizures compared with any other period of life. The author …