Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, the genes encoding polycystin 1 (PC1) and polycystin 2 (PC2), respectively. PC1 and …

Mutations in PKD1 cause the majority of cases of autosomal dominant polycystic kidney
disease (ADPKD). Because polycystin 1 modulates cell proliferation, cell differentiation, and …

The primary structure of polycystin predicts a large integral membrane protein with multiple
cell recognition motifs, but its function remains unknown. Insight into polycystin's normal …

Abstract Polycystin-1 (PC-1), the PKD1 gene product, is a large receptor whose expression
in renal epithelial cells results in resistance to apoptosis and tubulogenesis, a model …

Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease
caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder
affecting 1 in 1,000 people in the general population and accounts for up to 10% of all …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common progressive
hereditary kidney disease. In 85–90% of cases, ADPKD results from a mutation in the PKD1 …

Polycystin-1, the product of the PKD1 gene, is a membrane-bound multidomain protein with
a unique structure and a molecular weight of≈ 460 kD. The purpose of this study is to …

Polycystic kidney disease (PKD), in which epithelial cysts arise from or instead of normal
renal tubules, is one of the most common genetic diseases. It has both autosomal dominant …

Although much is known about the molecular genetic mechanisms of autosomal-dominant
polycystic kidney disease (ADPKD), few effective treatment is currently available. Here, we …