[HTML][HTML] Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908)
G Moore, S Liao, JA Curci, BC Starcher… - Journal of vascular …, 1999 - Elsevier
Background: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation,
disruption of medial elastin, and increased local production of elastolytic matrix …
disruption of medial elastin, and increased local production of elastolytic matrix …
[HTML][HTML] The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms
Purpose: Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade the
extracellular matrix of the aortic wall and lead to the formation of abdominal aortic …
extracellular matrix of the aortic wall and lead to the formation of abdominal aortic …
[HTML][HTML] Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated …
D Petrinec, S Liao, DR Holmes, JM Reilly… - Journal of vascular …, 1996 - Elsevier
Purpose: Increased local production of matrix metalloproteinases (MMPs) is a potential
mechanism underlying structural protein degradation in abdominal aortic aneurysms (AAA) …
mechanism underlying structural protein degradation in abdominal aortic aneurysms (AAA) …
[HTML][HTML] Pharmacologic suppression of experimental abdominal aortic aneurysms: a comparison of doxycycline and four chemically modified tetracyclines
JA Curci, D Petrinec, S Liao, LM Golub… - Journal of vascular …, 1998 - Elsevier
Background: Matrix metalloproteinases (MMPs) likely contribute to the degradation of medial
elastin in abdominal aortic aneurysms (AAAs), and tetracycline antibiotics exhibit MMP …
elastin in abdominal aortic aneurysms (AAAs), and tetracycline antibiotics exhibit MMP …
Role of matrix metalloproteinase inhibitors in preventing abdominal aortic aneurysm
F Aziz, H Kuivaniemi - Annals of vascular surgery, 2007 - Elsevier
Abdominal aortic aneurysm (AAA) is a significant health problem in the United States, with
approximately 30,000 repair operations annually. Treatment of AAA is associated with more …
approximately 30,000 repair operations annually. Treatment of AAA is associated with more …
Marimastat inhibits elastin degradation and matrix metalloproteinase 2 activity in a model of aneurysm disease
GD Treharne, JR Boyle, S Goodall… - Journal of British …, 1999 - academic.oup.com
Background Abdominal aortic aneurysms are characterized by degradation of the
extracellular matrix, with a reduction in the elastin concentration of the arterial media. These …
extracellular matrix, with a reduction in the elastin concentration of the arterial media. These …
Amlodipine potentiates metalloproteinase activity and accelerates elastin degradation in a model of aneurysmal disease
JR Boyle, IM Loftus, S Goodall, M Crowther… - European journal of …, 1998 - Elsevier
AIMS:: abdominal aortic aneurysms are characterised by changes in the extracellular matrix
of the arterial media, in particular a reduction in elastin concentration. These changes are …
of the arterial media, in particular a reduction in elastin concentration. These changes are …
MMP inhibition in abdominal aortic aneurysms: rationale for a prospective randomized clinical trial
RW Thompson, BT Baxter - Annals of the New York Academy of …, 1999 - Wiley Online Library
Abdominal aortic aneurysms (AAAs) represent a chronic degenerative condition associated
with a life‐threatening risk of rupture. The evolution of AAAs is thought to involve the …
with a life‐threatening risk of rupture. The evolution of AAAs is thought to involve the …
[HTML][HTML] Simvastatin suppresses experimental aortic aneurysm expansion
A Kalyanasundaram, JR Elmore, JR Manazer… - Journal of vascular …, 2006 - Elsevier
OBJECTIVE: Abdominal aortic aneurysm (AAA) formation is a result of inflammation and
extracellular matrix (ECM) remodeling mediated by matrix metalloproteinases (MMPs) …
extracellular matrix (ECM) remodeling mediated by matrix metalloproteinases (MMPs) …
[HTML][HTML] Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease
JR Boyle, E McDermott, M Crowther, AD Wills… - Journal of vascular …, 1998 - Elsevier
Purpose: Abdominal aortic aneurysms are characterized by degradation of the extracellular
matrix, with a reduction in the elastin concentration of the arterial media. These changes are …
matrix, with a reduction in the elastin concentration of the arterial media. These changes are …