Methylation patterns are the result of de novo methylation, demethylation, and the
maintenance of existing methylation. Although the existence and identity of an active …

Mammalian development is associated with considerable changes in global DNA
methylation levels at times of genomic reprogramming. Normal DNA methylation is essential …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is a common epigenetic modification found in eukaryotic organisms
ranging from fungi to mammals. Over the past 15 years, a number of eukaryotic DNA …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

Decades of investigation on DNA methylation have led to deeper insights into its metabolic
mechanisms and biological functions. This understanding was fueled by the recent …

Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA
methylation patterns that are required for proper epigenetic regulation of gene expression …