Understanding posttraumatic stress disorder: insights from the methylome
S Malan‐Müller, S Seedat… - Genes, Brain and …, 2014 - Wiley Online Library
Genome‐wide association studies (GWAS) have identified numerous disease‐associated
variants; however, these variants have a minor effect on disease and explain only a small …
variants; however, these variants have a minor effect on disease and explain only a small …
DNA methylation correlates of PTSD: Recent findings and technical challenges
There is increasing evidence that epigenetic factors play a critical role in posttraumatic
stress disorder (PTSD), by mediating the impact of environmental exposures to trauma on …
stress disorder (PTSD), by mediating the impact of environmental exposures to trauma on …
The role of DNA methylation in stress-related psychiatric disorders
Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …
important factors in the long-term biological trajectories leading to stress-related psychiatric …
Epigenome‐wide association of PTSD from heterogeneous cohorts with a common multi‐site analysis pipeline
A Ratanatharathorn, MP Boks… - American Journal of …, 2017 - Wiley Online Library
Compelling evidence suggests that epigenetic mechanisms such as DNA methylation play a
role in stress regulation and in the etiologic basis of stress related disorders such as Post …
role in stress regulation and in the etiologic basis of stress related disorders such as Post …
[HTML][HTML] An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci
Background Previous studies using candidate gene and genome-wide approaches have
identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic …
identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic …
Successful treatment of post-traumatic stress disorder reverses DNA methylation marks
Epigenetic mechanisms play a role in the detrimental effects of traumatic stress and the
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …
Functional annotation of the human PTSD methylome identifies tissue-specific epigenetic variation across subcortical brain regions
Post-traumatic stress disorder is a mental disorder that may occur in the aftermath of severe
psychological trauma. We examined 1,065,750 DNA methylation (DNAm) sites from 171 …
psychological trauma. We examined 1,065,750 DNA methylation (DNAm) sites from 171 …
[HTML][HTML] An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders
Previous epigenome-wide association studies (EWAS) of posttraumatic stress disorder
(PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to …
(PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to …
[HTML][HTML] Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in US military veterans
Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric disorder
prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology …
prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology …
[HTML][HTML] Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder
Background Epigenetic mechanisms have been suggested to play a role in the development
of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data …
of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data …