3507 Background: The use of adjuvant chemotherapy in patients (pts) with stage II colon
cancer who lack “high-risk” features ([HiR] perforation, T4 disease and/or less than 12 lymph …

The present study was designed to explore the activity of platinum compounds in
cisplatinresistant cell lines, the unselected cell lines of the National Cancer Institute's …

The treatment for advanced gastroesophageal tumors is still largely based on 5-fluorouracil
and cisplatin combinations, and the treatment for advanced pancreatic tumors principally …

Oxaliplatin is the only third-generation platinum derivative to have found a place in routine
cancer therapy. It is particularly useful therapy for advanced colorectal cancer and has …

PURPOSE: Irinotecan and oxaliplatin are two new agents with promising activity in
advanced colorectal cancer. Based on preclinical and clinical evidence that both drugs act …

Aims and background As raltitrexed and oxaliplatin (L-OHP) are both effective in the
treatment of colorectal cancer but have different mechanisms of action, we studied the …

Oxaliplatin,(trans-R, R-cyclohexane-1, 2-diamine) oxalatoplatinum (II), has recently been
approved for combination chemotherapy of metastatic colorectal cancer. Oxaliplatin is …

Oxaliplatin is a third-generation platinum compound that has shown a wide range of anti-
tumour activity in metastatic cancer and in multiple cell lines. It contains a …

The cumulative pharmacokinetic pattern of oxaliplatin, a new diamminecyclohexane
platinum derivative, was studied in patients with metastatic colorectal cancer. Oxaliplatin …

Oxaliplatin has shown in vivo cytotoxic activity against colorectal cell lines. Preliminary
studies suggest potentiation of fluorouracil (5-FU). To assess this issue, we performed a …