Dynamic heterogeneity and DNA methylation in embryonic stem cells
Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each
exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these …
exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these …
Systematic analysis of the determinants of gene expression noise in embryonic stem cells
Isogenic cells in a common environment show substantial cell-to-cell variation in gene
expression, often referred to as" expression noise." Here, we use multiple single-cell RNA …
expression, often referred to as" expression noise." Here, we use multiple single-cell RNA …
Serum-based culture conditions provoke gene expression variability in mouse embryonic stem cells as revealed by single-cell analysis
Variation in gene expression is an important feature of mouse embryonic stem cells (ESCs).
However, the mechanisms responsible for global gene expression variation in ESCs are not …
However, the mechanisms responsible for global gene expression variation in ESCs are not …
A dynamical-systems view of stem cell biology
C Furusawa, K Kaneko - Science, 2012 - science.org
During development, cells undergo a unidirectional course of differentiation that
progressively decreases the number of cell types they can potentially become. Stem cells …
progressively decreases the number of cell types they can potentially become. Stem cells …
Systems-level dynamic analyses of fate change in murine embryonic stem cells
Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …
Inferring the kinetics of stochastic gene expression from single-cell RNA-sequencing data
JK Kim, JC Marioni - Genome biology, 2013 - Springer
Background Genetically identical populations of cells grown in the same environmental
condition show substantial variability in gene expression profiles. Although single-cell RNA …
condition show substantial variability in gene expression profiles. Although single-cell RNA …
Noise-driven stem cell and progenitor population dynamics
Background The balance between maintenance of the stem cell state and terminal
differentiation is influenced by the cellular environment. The switching between these states …
differentiation is influenced by the cellular environment. The switching between these states …
Oscillatory protein expression dynamics endows stem cells with robust differentiation potential
N Suzuki, C Furusawa, K Kaneko - PloS one, 2011 - journals.plos.org
The lack of understanding of stem cell differentiation and proliferation is a fundamental
problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell …
problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell …
Making lineage decisions with biological noise: Lessons from the early mouse embryo
CS Simon, AK Hadjantonakis… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Understanding how individual cells make fate decisions that lead to the faithful formation
and homeostatic maintenance of tissues is a fundamental goal of contemporary …
and homeostatic maintenance of tissues is a fundamental goal of contemporary …
Transcriptome-wide variability in single embryonic development cells
V Piras, M Tomita, K Selvarajoo - Scientific reports, 2014 - nature.com
Molecular heterogeneity of individual molecules within single cells has been recently shown
to be crucial for cell fate diversifications. However, on a global scale, the effect of molecular …
to be crucial for cell fate diversifications. However, on a global scale, the effect of molecular …
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