Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each
exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these …

Isogenic cells in a common environment show substantial cell-to-cell variation in gene
expression, often referred to as" expression noise." Here, we use multiple single-cell RNA …

Variation in gene expression is an important feature of mouse embryonic stem cells (ESCs).
However, the mechanisms responsible for global gene expression variation in ESCs are not …

During development, cells undergo a unidirectional course of differentiation that
progressively decreases the number of cell types they can potentially become. Stem cells …

Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …

Background Genetically identical populations of cells grown in the same environmental
condition show substantial variability in gene expression profiles. Although single-cell RNA …

The lack of understanding of stem cell differentiation and proliferation is a fundamental
problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell …

Molecular heterogeneity of individual molecules within single cells has been recently shown
to be crucial for cell fate diversifications. However, on a global scale, the effect of molecular …

Understanding how individual cells make fate decisions that lead to the faithful formation
and homeostatic maintenance of tissues is a fundamental goal of contemporary …

Individual mouse embryonic stem cells have been found to exhibit highly variable
differentiation responses under the same environmental conditions. The noisy cyclic …