Heterogeneous expression of the transcription factor NANOG has been linked to the
existence of various functional states in pluripotent stem cells. This heterogeneity seems to …

Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal
genome stability and karyotype in culture. We previously showed that infrequent bursts of …

Signal transduction networks allow eukaryotic cells to make decisions based on information
about intracellular state and the environment. Biochemical noise significantly diminishes the …

Human embryonic stem cells (hESCs) share an identical genome with lineage-committed
cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse …

To decipher cell state transitions from single-cell transcriptomes it is crucial to quantify weak
expression of lineage-determining factors, which requires computational methods that are …

Pluripotent stem cells provide a powerful system to dissect the underlying molecular
dynamics that regulate cell fate changes during mammalian development. Here we report …