The notion that gene silencing after methylation of promoters of tumor suppresser genes
results in carcinogenesis is supported by many lines of evidence. Myelodysplastic syndrome …

In their paper published in this issue of Leukemia, Aoki and et al1 have addressed important
questions regarding the mechanisms mediating a regional, inactiving promoter methylation …

Aberrant hypermethylation of tumor suppressor genes plays an important role in the
development of many tumors. Recently identified new DNA methyltransferase (DNMT) …

p15INK4b gene is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6 whose
expression is induced by transforming growth factor (TGF) β. Recent reports suggest …

Myelodysplastic syndromes (MDS) are clonal disorders, which frequently undergo leukemic
transformation. It was recently shown that the promoter of the p15 INK4b but not the p …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …

Recent studies have elucidated that not only genetic alterations but also epigenetic changes
may play an important role in carcinogenesis. In particular, de novo methylation of CpG …

DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …

Recent work has identified heterozygous mutations in DNMT3a in 4.1–22.1% of patients
with acute myeloid leukemia (AML). 1, 2 Here we show that 3.3% of patients with high risk …

Hypermethylation of CpG islands within the promoter region is one of the mechanisms by
which genes are inactivated and may be one of the reason for silencing of cell cycle control …