Sequence‐specific DNA binding by AT‐hook motifs in Me CP 2
MJ Lyst, J Connelly, C Merusi, A Bird - FEBS letters, 2016 - Wiley Online Library
Me CP 2 is a chromatin‐associated protein that is mutated in Rett syndrome. Its methyl‐CpG‐
binding domain interacts with DNA containing methylated cytosine, but other modes of …
binding domain interacts with DNA containing methylated cytosine, but other modes of …
[HTML][HTML] By hook or by crook: multifaceted DNA-binding properties of MeCP2
Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause
Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in …
Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in …
[HTML][HTML] MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome
T Nikitina, RP Ghosh, RA Horowitz-Scherer… - Journal of Biological …, 2007 - ASBMB
hMeCP2 (human methylated DNA-binding protein 2), mutations of which cause most cases
of Rett syndrome (RTT), is involved in the transmission of repressive epigenetic signals …
of Rett syndrome (RTT), is involved in the transmission of repressive epigenetic signals …
MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
RP Ghosh, RA Horowitz-Scherer… - … and cellular biology, 2010 - Am Soc Microbiol
Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …
[HTML][HTML] A novel DNA-binding feature of MeCP2 contributes to Rett syndrome
X Xu, L Pozzo-Miller - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder associated with
intellectual disabilities, which almost exclusively affects females during early childhood with …
intellectual disabilities, which almost exclusively affects females during early childhood with …
MeCP2 Rett mutations affect large scale chromatin organization
Rett syndrome is a neurological, X chromosomal-linked disorder associated with mutations
in the MECP2 gene. MeCP2 protein has been proposed to play a role in transcriptional …
in the MECP2 gene. MeCP2 protein has been proposed to play a role in transcriptional …
Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin
T Nikitina, X Shi, RP Ghosh… - … and cellular biology, 2007 - Am Soc Microbiol
Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …
Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin
Abstract Methylated CpG Binding Protein 2 (MeCP2) is a nuclear protein named for its ability
to selectively recognize methylated DNA. Much attention has been focused on …
to selectively recognize methylated DNA. Much attention has been focused on …
MeCP2_E1 N-terminal modifications affect its degradation rate and are disrupted by the Ala2Val Rett mutation
Abstract Methyl CpG-binding protein 2 (MeCP2), the mutated protein in Rett syndrome
(RTT), is a crucial chromatin-modifying and gene-regulatory protein that has two main …
(RTT), is a crucial chromatin-modifying and gene-regulatory protein that has two main …
Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein …
A Kumar, S Kamboj, BM Malone, S Kudo… - Journal of cell …, 2008 - journals.biologists.com
The methyl-CpG-binding protein 2 (MECP2) serves both organizational and transcriptional
functions in the nucleus, with two well-characterized domains integrally related to these …
functions in the nucleus, with two well-characterized domains integrally related to these …