Structural basis for DNMT3A-mediated de novo DNA methylation
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …
cytosines is essential for genome regulation and development,. Dysregulation of this …
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
Mammalian DNA methylation patterns are established by two de novo DNA
methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive …
methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive …
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
Genetic imprinting, found in flowering plants and placental mammals, uses DNA methylation
to yield gene expression that is dependent on the parent of origin. DNA methyltransferase …
to yield gene expression that is dependent on the parent of origin. DNA methyltransferase …
Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
CC Lin, YP Chen, WZ Yang, JCK Shen… - Nucleic acids …, 2020 - academic.oup.com
DNA methyltransferases are primary enzymes for cytosine methylation at CpG sites of
epigenetic gene regulation in mammals. De novo methyltransferases DNMT3A and …
epigenetic gene regulation in mammals. De novo methyltransferases DNMT3A and …
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
SJ Kim, H Zhao, S Hardikar, AK Singh… - Blood, The Journal …, 2013 - ashpublications.org
Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …
frequently in acute myeloid leukemia and other hematological malignancies, with the …
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
Abstract DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
Large conserved domains of low DNA methylation maintained by Dnmt3a
Gains and losses in DNA methylation are prominent features of mammalian cell types. To
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …
DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
S Adam, H Anteneh, M Hornisch, V Wagner… - Nature …, 2020 - nature.com
DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for
mammalian development and differentiation and is frequently dysregulated in cancer. These …
mammalian development and differentiation and is frequently dysregulated in cancer. These …
DNMT3A in Leukemia
L Brunetti, MC Gundry… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …
Although the advent of new molecular techniques has enhanced our knowledge of how …