Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of
active genes, and the extent of methylation biology conservation is unclear. We quantified …

Cytosine methylation plays a crucial role in the regulation of gene expression and the
control of genome stability in higher eukaryotes. Despite its importance for normal …

Epigenetics can be defined as the study of heritable changes in gene expression without
alteration of the DNA sequence itself. This means that epigenetic variants are stable …

Methylation of cytosines is a pervasive feature of eukaryotic genomes and an important
epigenetic layer that is fundamental for cellular differentiation processes and control of …

DNA methylation is one of the most important heritable epigenetic modifications of the
genome and is involved in the regulation of many cellular processes. Aberrant DNA …

DNA methylation is an epigenetic modification with a very long evolutionary history.
However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome …

Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA
methylation has an important role in many aspects of biology, including development and …

The primary sequence of the genome is broadly constant and superimposed upon that
constancy is the postreplicative modification of a small number of cytosine residues to 5 …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …