DNA methylation is an epigenetic mark crucial in regulation of gene expression. Aberrant
DNA methylation causes silencing of tumor suppressor genes and promotes chromosomal …

Global changes in DNA methylation correlate with altered gene expression and genomic
instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) …

Aberrant DNA methylation at CpG dinucleotides can result in epigenetic silencing of tumour
suppressor genes and represents one of the earliest events in tumourigenesis. To date …

Using a unique microarray platform for cytosine methylation profiling, the DNA methylation
landscape of the human genome was monitored at more than 21 000 sites, including 79% of …

Alterations of the DNA methylation pattern have been related to generalized chromosomal
disruption and inactivation of multiple tumor suppressor genes in neoplasia. To screen for …

Gene silencing via promoter CpG island hypermethylation offers tumor cells growth
advantages. This epigenetic event is pharmacologically reversible, and uncovering a unique …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

Alteration in epigenetic regulation of gene expression is a common event in human cancer
and developmental disease. CpG island hypermethylation and consequent gene silencing …

DNA methylation of promoter CpG islands is strongly associated with gene silencing and is
known as a frequent cause of loss of expression of tumor suppressor genes, as well as other …

DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …