Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease
JJ Chen, B Uthayakumar… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD)
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
Neurovascular and neurometabolic couplings in dynamic calibrated fMRI: transient oxidative neuroenergetics for block-design and event-related paradigms
Functional magnetic resonance imaging (fMRI) with blood-oxygenation level dependent
(BOLD) contrast is an important tool for mapping brain activity. Interest in quantitative fMRI …
(BOLD) contrast is an important tool for mapping brain activity. Interest in quantitative fMRI …
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states
M Xu, B Bo, M Pei, Y Chen, CY Shu… - Journal of Cerebral …, 2022 - journals.sagepub.com
Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …
Calibrated fMRI for mapping absolute CMRO2: Practicalities and prospects
M Germuska, RG Wise - Neuroimage, 2019 - Elsevier
Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern
neuroscience, providing valuable insight into the functional organisation of the brain. The …
neuroscience, providing valuable insight into the functional organisation of the brain. The …
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
[HTML][HTML] Assessing the repeatability of absolute CMRO2, OEF and haemodynamic measurements from calibrated fMRI
A Merola, MA Germuska, K Murphy, RG Wise - Neuroimage, 2018 - Elsevier
As energy metabolism in the brain is largely oxidative, the measurement of cerebral
metabolic rate of oxygen consumption (CMRO 2) is a desirable biomarker for quantifying …
metabolic rate of oxygen consumption (CMRO 2) is a desirable biomarker for quantifying …
Calibrated functional MRI: mapping the dynamics of oxidative metabolism
TL Davis, KK Kwong, RM Weisskoff… - Proceedings of the …, 1998 - National Acad Sciences
MRI was extended to the measurement of changes in oxidative metabolism in the normal
human during functionally induced changes in cellular activity. A noninvasive MRI method …
human during functionally induced changes in cellular activity. A noninvasive MRI method …
Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation
EK Englund, MA Fernández-Seara… - Journal of Cerebral …, 2020 - journals.sagepub.com
Functional MRI (fMRI) can identify active foci in response to stimuli through BOLD signal
fluctuations, which represent a complex interplay between blood flow and cerebral …
fluctuations, which represent a complex interplay between blood flow and cerebral …
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