[HTML][HTML] Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis
Summary Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite,
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
P Pathak, RN Helsley, AL Brown… - American Journal …, 2020 - journals.physiology.org
The gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) has recently been
linked to cardiovascular disease (CVD) pathogenesis, prompting the development of …
linked to cardiovascular disease (CVD) pathogenesis, prompting the development of …
Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine-N-Oxide
KA Romano, EI Vivas, D Amador-Noguez, FE Rey - MBio, 2015 - Am Soc Microbiol
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which upon absorption by the host …
choline results in the production of trimethylamine (TMA), which upon absorption by the host …
Microbiome, trimethylamine N-oxide, and cardiometabolic disease
There is increasing appreciation that changes in microbiome composition and function can
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease
Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …
Targeted inhibition of gut microbial trimethylamine N-oxide production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic …
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet,
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation
J Kuka, E Liepinsh, M Makrecka-Kuka, J Liepins… - Life sciences, 2014 - Elsevier
Abstract Aims Trimethylamine-N-oxide (TMAO) is produced in host liver from trimethylamine
(TMA). TMAO and TMA share common dietary quaternary amine precursors, carnitine and …
(TMA). TMAO and TMA share common dietary quaternary amine precursors, carnitine and …
Trimethylamine N‐oxide generated by the gut microbiota is associated with vascular inflammation: new insights into atherosclerosis
Y Liu, M Dai - Mediators of inflammation, 2020 - Wiley Online Library
Trimethylamine N‐oxide (TMAO) is a biologically active molecule generated by the gut
microbiota. Accumulating evidences have indicated a close association between high …
microbiota. Accumulating evidences have indicated a close association between high …
Gut microbiota–derived trimethylamine N-oxide contributes to abdominal aortic aneurysm through inflammatory and apoptotic mechanisms
Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …
[HTML][HTML] The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases
J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …
Researchers have found that the occurrence and development of CVDs are closely related …