The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review

C Pivonello, M Negri, R Patalano, F Amatrudo… - Obesity …, 2022 - Wiley Online Library
Obesity is a chronic condition whose management is a critical challenge for physicians. The
scientific community has increased its focus on the molecular mechanisms involved in …

Mechanisms of melatonin in obesity: a review

Q Guan, Z Wang, J Cao, Y Dong, Y Chen - International journal of …, 2021 - mdpi.com
Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Melatonin in macrophage biology: Current understanding and future perspectives

Y Xia, S Chen, S Zeng, Y Zhao, C Zhu… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

Melatonin supplementation in the management of obesity and obesity-associated disorders: a review of physiological mechanisms and clinical applications

R Genario, J Cipolla-Neto, AA Bueno… - Pharmacological …, 2021 - Elsevier
Despite the evolving advances in clinical approaches to obesity and its inherent
comorbidities, the therapeutic challenge persists. Among several pharmacological tools …

Melatonin supplementation attenuates the pro-inflammatory adipokines expression in visceral fat from obese mice induced by a high-fat diet

TSM Farias, RI Paixao, MM Cruz, RDCC de Sa… - Cells, 2019 - mdpi.com
Obesity is defined as a condition of abnormal or excessive fat accumulation in white adipose
tissue that results from the exacerbated consumption of calories associated with low energy …

Melatonin supplementation decreases hypertrophic obesity and inflammation induced by high-fat diet in mice

TSM Farias, MM Cruz, RCC Sa, I Severi… - Frontiers in …, 2019 - frontiersin.org
Obesity results from critical periods of positive energy balance characterized by caloric
intake greater than energy expenditure. This disbalance promotes adipose tissue …

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation

N Ma, J Zhang, RJ Reiter, X Ma - Medicinal Research Reviews, 2020 - Wiley Online Library
Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm
regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal …

Anti-inflammatory effects of melatonin in obesity and hypertension

NJ Prado, L Ferder, W Manucha, ER Diez - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Here, we review the known relations between hypertension and
obesity to inflammation and postulate the endogenous protective effect of melatonin and its …

Melatonin reduces obesity and restores adipokine patterns and metabolism in obese (ob/ob) mice

G Favero, A Stacchiotti, S Castrezzati, F Bonomini… - Nutrition Research, 2015 - Elsevier
The increasing incidence of obesity, leading to metabolic complications, is now recognized
as a major public health problem. The adipocytes are not merely energy-storing cells, but …

[HTML][HTML] The mechanism of oral melatonin ameliorates intestinal and adipose lipid dysmetabolism through reducing Escherichia Coli-derived lipopolysaccharide

B Rong, Q Wu, RJ Reiter, C Sun - Cellular and molecular gastroenterology …, 2021 - Elsevier
Background & Aims Gut microbiota have been reported to be sensitive to circadian rhythms
and host lipometabolism, respectively. Although melatonin-mediated beneficial efforts on …