Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation …

L Torres, MA Avila, M Carretero, MU Latasa… - 2000 - dadun.unav.edu
Methionine adenosyltransferase (MAT) is the enzyme that catalyzes the synthesis of S-
adenosylmethionine (AdoMet), the main donor of methyl groups in the cell. In mammals MAT …

Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation

ML Tomasi, TWH Li, M Li, JM Mato… - Journal of cellular …, 2012 - Wiley Online Library
Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine
adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and …

Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells

JL Rodríguez, A Boukaba, J Sandoval… - The international journal …, 2007 - Elsevier
Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the
formation of S-adenosylmethionine, the main methyl donor. Two MAT-encoding genes …

S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the …

E Ruiz Garcia-Trevijano, MU Latasa, M Carretero… - 2000 - dadun.unav.edu
Methionine metabolism starts with the formation of S-adenosylmethionine (AdoMet), the
most important biological methyl donor. This reaction is catalyzed by methionine …

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation

SC Lu, L Alvarez, ZZ Huang, L Chen… - Proceedings of the …, 2001 - National Acad Sciences
Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of
two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S …

Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer

H Yang, ZZ Huang, Z Zeng, C Chen… - American Journal of …, 2001 - journals.physiology.org
Methionine adenosyltransferase (MAT), an essential enzyme that catalyzes the formation of
S-adenosylmethionine (SAM), is encoded by two genes, MAT1A (liver-specific) and MAT2A …

DNA methylation and histone acetylation of rat methionine adenosyltransferase 1A and 2A genes is tissue-specific

L Torres, G López-Rodas, MU Latasa… - The international journal …, 2000 - Elsevier
Methionine adenosyltransferase (MAT) catalyzes the biosynthesis of S-adenosylmethionine
(AdoMet). In mammals MAT activity derives from two separate genes which display a tissue …

Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells

J Cai, Z Mao, JJ Hwang, SC Lu - Cancer research, 1998 - AACR
Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosylmethionine
(SAM), the principal methyl donor, and is essential to normal cell function. The two forms of …

Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat

ZZ Huang, JM Mato, G Kanel, SC Lu - Hepatology, 1999 - journals.lww.com
Liver–specific and non-liver–specific methionine adenosyltransferase (MAT) are products of
two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S …

[HTML][HTML] Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice

J Li, K Ramani, Z Sun, C Zee, EG Grant, H Yang… - The American journal of …, 2010 - Elsevier
Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine,
the principal methyl donor, and is encoded by MAT1A and MAT2A in mammals. Normal liver …