Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …

Pluripotent stem cells provide a powerful system to dissect the underlying molecular
dynamics that regulate cell fate changes during mammalian development. Here we report …

Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …

A number of key regulators of mouse embryonic stem (ES) cell identity, including the
transcription factor Nanog, show strong expression fluctuations at the single-cell level. The …

In multicellular organisms, transcription regulation is one of the central mechanisms
modelling lineage differentiation and cell-fate determination. Transcription requires dynamic …

Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in
unipotent primordial germ cells (PGCs) in mice, where its precise role is yet unclear,,. We …

Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

Embryonic stem (ES) cells are pluripotent, and of therapeutic potential in regenerative
medicine,. Understanding pluripotency at the molecular level should illuminate fundamental …

Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …

Ontogeny describes the emergence of complex multicellular organisms from single
totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate …