DNA methylation and chromatin modification
HH Ng, B Adrian - Current opinion in genetics & development, 1999 - Elsevier
DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …
[HTML][HTML] CpG methylation, chromatin structure and gene silencing—a three-way connection
A Razin - The EMBO journal, 1998 - embopress.org
The three-way connection between DNA methylation, gene activity and chromatin structure
has been known for almost two decades. Nevertheless, the molecular link between methyl …
has been known for almost two decades. Nevertheless, the molecular link between methyl …
[HTML][HTML] DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease
A El-Osta, AP Wolffe - Gene expression, 2000 - ncbi.nlm.nih.gov
DNA methylation is a major determinant in the epigenetic silencing of genes. The
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
DNA methylation and silencing of gene expression
J Newell-Price, AJL Clark, P King - Trends in Endocrinology & Metabolism, 2000 - cell.com
DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA and the subsequent recruitment of binding …
mechanism involves the methylation of DNA and the subsequent recruitment of binding …
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
H Kimura, K Shiota - Journal of Biological Chemistry, 2003 - ASBMB
During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …
DNA methylation: the nuts and bolts of repression
TB Miranda, PA Jones - Journal of cellular physiology, 2007 - Wiley Online Library
DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …
organization and gene expression. DNA methylation can silence genes and repetitive …
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
Histone deacetylation plays an important role in methylated DNA silencing. Recent studies
indicated that the methyl-CpG-binding protein, MBD2, is a component of the MeCP1 histone …
indicated that the methyl-CpG-binding protein, MBD2, is a component of the MeCP1 histone …
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
JD Lewis, RR Meehan, WJ Henzel, I Maurer-Fogy… - Cell, 1992 - cell.com
Methylation of mammalian DNA can lead to repression of transcription and alteration of
chromatin structure. Recent evidence suggests that both effects are the result of an …
chromatin structure. Recent evidence suggests that both effects are the result of an …
DNA methylation, chromatin inheritance, and cancer
Cancer is a process driven by the accumulation of abnormalities in gene function. While
many of these changes are genetic, epigenetically mediated changes in gene expression …
many of these changes are genetic, epigenetically mediated changes in gene expression …
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