DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …

The three-way connection between DNA methylation, gene activity and chromatin structure
has been known for almost two decades. Nevertheless, the molecular link between methyl …

DNA methylation is a major determinant in the epigenetic silencing of genes. The
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …

DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …

DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA and the subsequent recruitment of binding …

During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …

DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …

Histone deacetylation plays an important role in methylated DNA silencing. Recent studies
indicated that the methyl-CpG-binding protein, MBD2, is a component of the MeCP1 histone …

Methylation of mammalian DNA can lead to repression of transcription and alteration of
chromatin structure. Recent evidence suggests that both effects are the result of an …

Cancer is a process driven by the accumulation of abnormalities in gene function. While
many of these changes are genetic, epigenetically mediated changes in gene expression …