Animals constantly receive and respond to external or internal stimuli, and these
experiences are learned and memorized in their brains. In animals, this is a crucial feature …

Dynamic variations in DNA methylation regulate neuronal gene expression in an experience-
dependent manner. Although DNA methylation has been implicated in synaptic plasticity …

DNA methylation was once considered to be a static epigenetic modification whose primary
function was restricted to directing the development of cellular phenotype. However, it is now …

DNA methylation was traditionally viewed as a static mechanism required during cell fate
determination. This view has been challenged and it is now accepted that DNA methylation …

The establishment of synaptic plasticity and long-term memory requires lasting cellular and
molecular modifications that, as a whole, must endure despite the rapid turnover of their …

Over the last decade, an increasing number of reports underscored the importance of
epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and …

Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …

An organism's ability to adapt to its environment depends on its ability to regulate and
maintain tissue specific, temporal patterns of gene transcription in response to specific …

Cytosine DNA methylation is a stable epigenetic modification with established roles in
regulating transcription, imprinting, female X-chromosome inactivation, and silencing of …

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …