Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics
F Fakhouri, V Frémeaux-Bacchi - Nature Reviews Nephrology, 2021 - nature.com
Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …
[HTML][HTML] Complement in secondary thrombotic microangiopathy
LMP Palma, M Sridharan, S Sethi - Kidney international reports, 2021 - Elsevier
Thrombotic microangiopathy (TMA) is a condition characterized by thrombocytopenia and
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …
Atypical aHUS: state of the art
CM Nester, T Barbour, SR de Cordoba… - Molecular …, 2015 - Elsevier
Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs)
have revealed distinct disease mechanisms within this heterogeneous group of diseases. As …
have revealed distinct disease mechanisms within this heterogeneous group of diseases. As …
Atypical hemolytic‐uremic syndrome: an update on pathophysiology, diagnosis, and treatment
R Raina, V Krishnappa, T Blaha, T Kann… - Therapeutic …, 2019 - Wiley Online Library
Atypical hemolytic uremic syndrome (aHUS), a rare variant of thrombotic microangiopathy, is
characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal …
characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal …
[HTML][HTML] Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities
SA Timmermans, MA Abdul-Hamid, J Vanderlocht… - Kidney international, 2017 - Elsevier
Thrombotic microangiopathy (TMA) is a pattern of endothelial damage that can be found in
association with diverse clinical conditions such as malignant hypertension. Although the …
association with diverse clinical conditions such as malignant hypertension. Although the …
Maternal and fetal outcomes of pregnancies in women with atypical hemolytic uremic syndrome
Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the
alternative pathway of complement, or the proteins that regulate this pathway, and life …
alternative pathway of complement, or the proteins that regulate this pathway, and life …
Atypical hemolytic uremic syndrome in the setting of complement-amplifying conditions: case reports and a review of the evidence for treatment with eculizumab
Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, progressive, life-threatening
form of thrombotic microangiopathy (TMA) predominantly caused by dysregulation of the …
form of thrombotic microangiopathy (TMA) predominantly caused by dysregulation of the …
Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy caused by
uncontrolled activation of the alternative pathway of complement at the cell surface level that …
uncontrolled activation of the alternative pathway of complement at the cell surface level that …
Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: a focus on eculizumab
J Schmidtko, S Peine, Y El-Housseini… - American Journal of …, 2013 - Elsevier
Uncontrolled complement activation is central to the occurrence of atypical hemolytic uremic
syndrome (aHUS) and can result in thrombotic microangiopathies (TMAs). These terms …
syndrome (aHUS) and can result in thrombotic microangiopathies (TMAs). These terms …
An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document
JM Campistol, M Arias Ballesteros, G Ariceta, M Blasco… - 2013 - digital.csic.es
[EN] Haemolytic uraemic syndrome (HUS) is a clinical entitydefined as the triad of
nonimmune haemolytic anaemia, thrombocytopenia, and acute renal failure, in which …
nonimmune haemolytic anaemia, thrombocytopenia, and acute renal failure, in which …