Parkinson's disease (PD) is the second most common neurodegenerative disease in the
United States. Decades before motor symptoms manifest, non-motor symptoms such as …

Understanding the contribution of immune mechanisms to Parkinson's disease
pathogenesis is an important challenge, potentially of major therapeutic implications. To …

Abstract Although Parkinson's Disease (PD) is typically described in terms of motor
symptoms, depression is a common feature. We explored whether depression influences …

Laboratory tests for Parkinson's disease (PD) were recently extended to microarray analyses
of nucleated blood cells. Here, we report the use of statistical and gene ontology tools to re …

Objectives Patients with established Parkinson's disease (PD) display differences in
peripheral blood markers of immune function, including leukocyte differential counts …

Recent evidence suggests that innate and adaptive immunity play a crucial role in
Parkinson's disease (PD). However, studies regarding specific immune cell classification in …

Background: The motor impairment in Parkinson's disease (PD) can be managed but
effective treatments for stopping or slowing the disease process are lacking. The advent of …

Microglia are the main immune cells of the brain and express a large genetic pattern of
genes linked to Parkinson's disease risk alleles. Monocytes like microglia are myeloid …

Background Previous observational studies have suggested a correlation between immune
cells and Parkinson's disease (PD), yet specific investigations into the causal relationship …

The innate immune system is implicated in Parkinson's disease (PD), but peripheral in-vivo
clinical evidence of the components and driving mechanisms involved and their relationship …