Chronic lymphocytic leukaemia (CLL) is a disease with a highly variable prognosis. The
clinical course can however be predicted thanks to prognostic markers. Poor prognosis is …

The expression of ZAP-70 in a subset of chronic lymphocytic leukemia (CLL) patients
strongly correlates with a more aggressive clinical course, although the exact underlying …

Although the mutational status of the immunoglobulin variable region (IgVH) genes remains
the gold standard for prognostic markers in chronic lymphocytic leukaemia (CLL), it is a …

B-cell chronic lymphocytic leukaemia (CLL) is a heterogenous disease with highly variable
clinical course [1–3]. Currently, Ig Vh genes mutation status is considered as one of the most …

ZAP70 has a prognostic value in chronic lymphocytic leukemia (CLL), through altered B‐cell
receptor signaling, which is important in CLL pathogenesis. A good correlation between …

Chronic lymphocytic leukemia (CLL) B cells that express unmutated immunoglobulin heavy-
chain variable region genes (IgVH) generally express ZAP-70, in contrast to normal B cells …

Expression of ZAP-70 in a subset of patients with chronic lymphocytic leukemia (CLL)
positively correlates with the absence of immunoglobulin heavy-chain gene (IGHV) …

ZAP-70 tyrosine kinase is involved in signalling pathways following T-cell receptor
stimulation and was originally described only in T cells and natural killer cells. ZAP-70 …

We examined isolated leukemia B cells of patients with chronic lymphocytic leukemia (CLL)
for expression of zeta-associated protein 70 (ZAP-70). CLL B cells that have nonmutated …

Background Chronic lymphocytic leukemia (CLL) is heterogeneous with respect to
prognosis and clinical outcome. Mutational status of immunoglobulin heavy chain variable …