DNA methylation pattern in human zygotes and developing embryos
H Fulka, M Mrazek, O Tepla, J Fulka - Reproduction, 2004 - rep.bioscientifica.com
We report on observations of the global methylation/demethylation pattern of both pronuclei
in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate …
in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate …
Aberrant methylation patterns at the two‐cell stage as an indicator of early developmental failure
W Shi, T Haaf - Molecular Reproduction and Development …, 2002 - Wiley Online Library
The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …
fertilization, whereas the maternal genome is only passively demethylated by a replication …
Genome-wide methylation patterns in normal and uniparental early mouse embryos
SC Barton, KL Arney, W Shi, A Niveleau… - Human Molecular …, 2001 - academic.oup.com
In the normal diploid mouse embryo, active demethylation of the paternal genome but not of
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …
Dynamics of DNA‐demethylation in early mouse and rat embryos developed in vivo and in vitro
I Zaitseva, S Zaitsev, N Alenina, M Bader… - Molecular …, 2007 - Wiley Online Library
Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …
DNA methylation and embryogenesis
A Razin, H Cedar - DNA methylation: molecular biology and biological …, 1993 - Springer
A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …
and repeated sequences in different tissues of various mammalian species. This has …
Alterations of DNA methylation patterns in germ cells and Sertoli cells from developing mouse testis
H Coffigny, C Bourgeois, M Ricoul… - Cytogenetics and cell …, 1999 - karger.com
In situ alterations of DNA methylation were studied between 14 d postcoitum and 4 d
postpartum in Sertoli cells and germ cells from mouse testis, using anti-5-methylcytosine …
postpartum in Sertoli cells and germ cells from mouse testis, using anti-5-methylcytosine …
Methylation levels of maternal and paternal genomes during preimplantation development
SK HOWLETT, W REIK - Development, 1991 - journals.biologists.com
The methylation status of three highly repeated sequences was studied in sperm, eggs and
preimplantation embryos with different combinations of parental chromosomes. High levels …
preimplantation embryos with different combinations of parental chromosomes. High levels …
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
M Monk, M Boubelik, S Lehnert - Development, 1987 - journals.biologists.com
This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …
occurring during embryonic development. The egg genome is strikingly undermethylated …
Active demethylation of the paternal genome in the mouse zygote
J Oswald, S Engemann, N Lane, W Mayer, A Olek… - Current Biology, 2000 - cell.com
DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …
mammals [1]. Mammalian development is accompanied by two major waves of genome …
Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos
W Shi, F Dirim, E Wolf, V Zakhartchenko… - Biology of …, 2004 - academic.oup.com
Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
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