Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues
S Ghosh, AJ Yates, MC Frühwald, JC Miecznikowski… - Epigenetics, 2010 - Taylor & Francis
Although most CpG islands are generally thought to remain unmethylated in all adult
somatic tissues, recent genome-wide approaches have found that some CpG islands have …
somatic tissues, recent genome-wide approaches have found that some CpG islands have …
CpG methylation differences between neurons and glia are highly conserved from mouse to human
NJ Kessler, TE Van Baak, MS Baker… - Human molecular …, 2016 - academic.oup.com
Understanding epigenetic differences that distinguish neurons and glia is of fundamental
importance to the nascent field of neuroepigenetics. A recent study used genome-wide …
importance to the nascent field of neuroepigenetics. A recent study used genome-wide …
[HTML][HTML] Tissue-specific variation in DNA methylation levels along human chromosome 1
Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …
gene expression and suppressing spurious transcription. Most methods to scan the genome …
[HTML][HTML] A novel CpG island set identifies tissue-specific methylation at developmental gene loci
CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient
human genome and associate with many gene promoters. As CGIs also differ from bulk …
human genome and associate with many gene promoters. As CGIs also differ from bulk …
Fundamental diversity of human CpG islands at multiple biological levels
CpG islands (CGIs) are commonly used as genomic markers to study the patterns and
regulatory consequences of DNA methylation. Interestingly, recent studies reveal a …
regulatory consequences of DNA methylation. Interestingly, recent studies reveal a …
Role of CpG context and content in evolutionary signatures of brain DNA methylation
Y Xin, AH O'Donnell, Y Ge, B Chanrion, M Milekic… - Epigenetics, 2011 - Taylor & Francis
DNA methylation is essential in brain function and behavior; therefore, understanding the
role of DNA methylation in brain-based disorders begins with the study of DNA methylation …
role of DNA methylation in brain-based disorders begins with the study of DNA methylation …
[HTML][HTML] Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
Background DNA methylation is thought to play an important role in the regulation of
mammalian gene expression, partly based on the observation that a lack of CpG island …
mammalian gene expression, partly based on the observation that a lack of CpG island …
A new class of tissue‐specifically methylated regions involving entire CpG islands in the mouse
CpG islands, which have higher GC content and CpG frequencies compared to the genome
as a whole, are generally believed to be unmethylated in tissues except at promoters of …
as a whole, are generally believed to be unmethylated in tissues except at promoters of …
[HTML][HTML] Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …
interest, but remains poorly understood. We performed comprehensive DNA methylation …
[HTML][HTML] Putative zinc finger protein binding sites are over-represented in the boundaries of methylation-resistant CpG islands in the human genome
Background Majority of CpG dinucleotides in mammalian genomes tend to undergo DNA
methylation, but most CpG islands are resistant to such epigenetic modification …
methylation, but most CpG islands are resistant to such epigenetic modification …