Aberrant imprinting in spermatozoa in a subset of infertile men has been postulated to be a
risk factor for congenital diseases in children conceived via assisted reproduction …

OBJECTIVE: To study the methylation imprinting marks of two oppositely imprinted genes,
H19 and MEST/PEG1, in human testicular spermatozoa from azoospermic patients with …

Disorders in genetic imprinting are discussed as potential genetic risk in assisted
reproduction technology (ART), where most of the natural selection mechanisms are …

DNA methylation marks, a key modification of imprinting, are erased in primordial germ cells
and sex specifically re-established during gametogenesis. Abnormal epigenetic …

Male factor infertility has been associated with abnormal DNA methylation at imprinted
genes. Little information is available on the status of imprinting in the sperm of men with …

OBJECTIVE: To evaluate the associations between proper protamine incorporation and
DNA methylation at imprinted loci. DESIGN: Experimental research study. SETTING …

Genomic imprinting marks in the male germ line are already established in the adult
germinal stem cell population. We studied the methylation patterns of H19 and MEST …

Recent studies suggest that assisted reproductive technologies (ART), which involve the
isolation, handling and culture of gametes and early embryos, are associated with an …

Background Male infertility is a complex disease caused by a combination of genetic,
environmental, and lifestyle factors. Abnormal epigenetic programming has been proposed …

Considering the widespread use of assisted reproductive techniques (ART), DNA
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …