Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats

T Gali Ramamoorthy, TJ Allen, A Davies… - International Journal of …, 2018 - nature.com
Background and objective Maternal overnutrition has been implicated in affecting the
offspring by programming metabolic disorders such as obesity and diabetes, by …

[HTML][HTML] Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways

L Dearden, S Buller, IC Furigo… - Molecular …, 2020 - Elsevier
Objective Perinatal exposure to maternal obesity results in predisposition of offspring to
develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity …

Maternal high-fat diet leads to hippocampal and amygdala dendritic remodeling in adult male offspring

Y Janthakhin, M Rincel, AM Costa… - …, 2017 - Elsevier
Early-life exposure to calorie-dense food, rich in fat and sugar, contributes to the increasing
prevalence of obesity and its associated adverse cognitive and emotional outcomes at …

Maternal obesity is necessary for programming effect of high-fat diet on offspring

CL White, MN Purpera… - American Journal of …, 2009 - journals.physiology.org
We tested the hypothesis that maternal consumption of dietary fat, independent from obesity,
increases serum leptin in neonatal pups and predisposes them to adult obesity. Female rats …

Fetal brain and placental programming in maternal obesity: A review of human and animal model studies

LL Shook, S Kislal, AG Edlow - Prenatal diagnosis, 2020 - Wiley Online Library
Both human epidemiologic and animal model studies demonstrate that prenatal and
lactational exposure to maternal obesity and high‐fat diet are associated with adverse …

Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression

BA Ikenasio-Thorpe, BH Breier… - Journal of …, 2007 - joe.bioscientifica.com
The escalating rates of obesity and type 2 diabetes have reached pandemic proportions. It
has been proposed that the risk of developing metabolic disorders in adult life is influenced …

Maternal obesity and neurodevelopmental and psychiatric disorders in offspring

AG Edlow - Prenatal diagnosis, 2017 - Wiley Online Library
There is a growing body of evidence from both human epidemiologic and animal studies
that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated …

Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue

N Murabayashi, T Sugiyama, L Zhang… - European Journal of …, 2013 - Elsevier
OBJECTIVES: Epidemiological and animal studies have shown that maternal obesity
predisposes the offspring to obesity and the metabolic syndrome, possibly via late-onset …

Newborns of obese parents have altered DNA methylation patterns at imprinted genes

A Soubry, SK Murphy, F Wang, Z Huang… - International journal of …, 2015 - nature.com
Background: Several epidemiologic studies have demonstrated associations between
periconceptional environmental exposures and health status of the offspring in later life …

DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 13½ years: Project Ice Storm

L Cao-Lei, KN Dancause, G Elgbeili, R Massart… - Epigenetics, 2015 - Taylor & Francis
Prenatal maternal stress (PNMS) in animals and humans predicts obesity and metabolic
dysfunction in the offspring. Epigenetic modification of gene function is considered one …