Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …

The human placenta is a maternal-fetal organ essential for normal fetal development and
maternal health. During pregnancy, the placenta undergoes many structural and functional …

Over the last 20-80 million years the mammalian placenta has taken on a variety of
morphologies through both divergent and convergent evolution. Recently we have shown …

This review provides an overview of the unique features of DNA methylation in the human
placenta. We discuss the importance of understanding placental development, structure …

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene
expression. We explored this concept in the placenta to define whether DNA methylation is …

As the 'gateway'to the fetus, the placenta is subject to a myriad of environmental factors,
each with the potential to alter placental epigenetic and gene expression profile. This can …

Throughout in utero development, the placenta plays a key role in controlling growth and
development. The placenta acts not only as a gatekeeper of nutrient and waste exchange …

The placenta acts not only as a conduit of nutrient and waste exchange between mother and
developing fetus, but also functions as a regulator of the intrauterine environment. Recent …

While the human genome sequence is relatively uniform between the cells of an individual,
the DNA methylation of the genome (methylome) has unique features in different cells …

Epigenetic variation is increasingly hypothesized as a mechanism underlying the effect of
the in utero environment on long-term postnatal health; however, there is currently little clear …