The genome of extraembryonic tissue, such as the placenta, is hypomethylated relative to
that in somatic tissues. However, the origin and role of this hypomethylation remains …

Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an
epigenetic mechanism that regulates gene expression and contributes to adaptive …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

Abstract Purpose of Review To summarize recent literature relating early-life environmental
exposures on DNA methylation in the placenta, to identify how variation in placental …

Introduction Preeclampsia (PE) is one of the leading causes of maternal mortality and
morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has …

DNA methylation and demethylation are crucial for modulating gene expression and
regulating cell differentiation. Functions and mechanisms of DNA methylation/demethylation …

Fetal growth is determined by the feto-placental genome interacting with the maternal in
utero environment. Failure of this interplay leads to poor placental development and fetal …

Prior DNA methylation (DNA-m) analyses have identified cytosine-phosphate-guanine
(CpG) sites, which show either a significant change or consistency during lifetime. However …

Genome-wide levels of DNA methylation vary between tissues, and compared with other
tissues, the placenta has been reported to demonstrate a global decrease in methylation as …