Difficulties associated with long-term culture of primary trophoblasts have proven to be a
major hurdle in their functional characterization. In order to circumvent this issue, several …

DNA methylation of CpGs located in two types of repetitive elements—LINE1 (L1) and Alu—
is used to assess “global” changes in DNA methylation in studies of human disease and …

The objective of this study was to analyze genome-wide differential methylation patterns in
maternal leukocyte DNA in early pregnant and non-pregnant states. This is an age and body …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

Epigenetic programming is essential for lineage differentiation, embryogenesis and
placentation in early pregnancy. In epigenetic association studies, DNA methylation is often …

In vitro fertilization (IVF) is one of the most effective and successful assisted reproductive
technologies. It is widely used to treat human infertility, and is also used for animal breeding …

The majority of congenital heart defects (CHDs) are thought to result from the interaction
between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

Background Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms
are not completely understood. DNA methylation, which includes maintenance methylation …