The effects of a diet rich in saturated fat on fatty liver formation and the related mechanisms
that induce fatty liver were examined. C57BL/6J mice were fed butter or safflower oil as a …

Insulin-resistant apoB/BATless mice have hypertriglyceridemia because of increased
assembly and secretion of very low density apolipoprotein B (apoB) and triglycerides …

The present study was performed to examine a hypothesis that peroxisome proliferator-
activated receptor γ (PPARγ) is implicated in high fat diet-induced liver steatosis. Mice were …

Peroxisome proliferator‐activated receptor‐α (PPARα) is a major transcriptional regulator of
lipid metabolism. It is activated by diverse chemicals such as fatty acids (FAs) and regulates …

De novo lipogenesis is an energy-expensive process whose role in adult mammals is poorly
understood. We generated mice with liver-specific inactivation of fatty-acid synthase (FAS), a …

Peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor that regulates
lipid metabolism and inflammatory responses. Certain PPARγ ligands improve nonalcoholic …

Peroxisome proliferator‐activated receptor (PPAR) γ is a nuclear receptor central to glucose
and lipid homeostasis. PPARγ role in nonalcoholic fatty liver disease is controversial …

PPARα is a ligand‐activated transcription factor involved in the regulation of nutrient
metabolism and inflammation. Although much is already known about the function of PPARα …

The peroxisome proliferator-activated receptor α (PPARα) has been implicated as a key
control of fatty acid catabolism during the cellular fasting. However, little is known regarding …

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries and has
become a serious public health concern. Although Western-style dietary patterns …