Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation
Y Kudo, K Tateishi, K Yamamoto, S Yamamoto… - Cancer …, 2012 - Wiley Online Library
Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic
hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the …
hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the …
5-Hydroxymethylcytosine: an epigenetic mark frequently deregulated in cancer
LI Kroeze, BA van der Reijden, JH Jansen - Biochimica et Biophysica Acta …, 2015 - Elsevier
Abstract The epigenetic mark 5-hydroxymethylcytosine (5hmC) has gained interest since
2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the …
2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the …
[HTML][HTML] Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic
modification involved in tissue differentiation and is frequently altered in cancer. Recent …
modification involved in tissue differentiation and is frequently altered in cancer. Recent …
Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis
A Carella, JR Tejedor, MG García… - … journal of cancer, 2020 - Wiley Online Library
Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–
eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild …
eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild …
Loss of Tet1-associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer
JP Thomson, R Ottaviano, EB Unterberger… - Cancer research, 2016 - AACR
Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at
repressed genes in the host tissue, but the preceding events driving this phenomenon are …
repressed genes in the host tissue, but the preceding events driving this phenomenon are …
Connections between TET proteins and aberrant DNA modification in cancer
DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …
TET proteins and 5‐methylcytosine oxidation in hematological cancers
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …
Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …
TET proteins and the control of cytosine demethylation in cancer
L Scourzic, E Mouly, OA Bernard - Genome medicine, 2015 - Springer
The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
Tet family proteins and 5-hydroxymethylcytosine in development and disease
L Tan, YG Shi - Development, 2012 - journals.biologists.com
Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …
5mC) has emerged as an important epigenetic modification that plays essential roles in …