A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies

B Lehne, AW Drong, M Loh, W Zhang, WR Scott… - Genome biology, 2015 - Springer
DNA methylation plays a fundamental role in the regulation of the genome, but the optimal
strategy for analysis of genome-wide DNA methylation data remains to be determined. We …

RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip

Z Xu, SAS Langie, P De Boever, JA Taylor, L Niu - BMC genomics, 2017 - Springer
Abstract Background The Illumina Infinium HumanMethylation450 BeadChip and its
successor, Infinium MethylationEPIC BeadChip, have been extensively utilized in …

[HTML][HTML] Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip

DL McCartney, RM Walker, SW Morris, AM McIntosh… - Genomics data, 2016 - Elsevier
Genome-wide analysis of DNA methylation has now become a relatively inexpensive
technique thanks to array-based methylation profiling technologies. The recently developed …

[HTML][HTML] Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data

TJ Morris, S Beck - Methods, 2015 - Elsevier
Abstract The Illumina HumanMethylation450 BeadChip has become a popular platform for
interrogating DNA methylation in epigenome-wide association studies (EWAS) and related …

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

R Pidsley, E Zotenko, TJ Peters, MG Lawrence… - Genome biology, 2016 - Springer
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …

RCP: a novel probe design bias correction method for Illumina Methylation BeadChip

L Niu, Z Xu, JA Taylor - Bioinformatics, 2016 - academic.oup.com
Abstract Motivation: The Illumina HumanMethylation450 BeadChip has been extensively
utilized in epigenome-wide association studies. This array and its successor, the …

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

EM Price, AM Cotton, LL Lam, P Farré, E Emberly… - Epigenetics & …, 2013 - Springer
Background Measurement of genome-wide DNA methylation (DNAm) has become an
important avenue for investigating potential physiologically-relevant epigenetic changes …

ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip

Z Xu, L Niu, L Li, JA Taylor - Nucleic acids research, 2016 - academic.oup.com
Abstract The Illumina HumanMethylation450 BeadChip is increasingly utilized in epigenome-
wide association studies, however, this array-based measurement of DNA methylation is …

missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform

B Phipson, J Maksimovic, A Oshlack - Bioinformatics, 2015 - academic.oup.com
DNA methylation is one of the most commonly studied epigenetic modifications due to its
role in both disease and development. The Illumina HumanMethylation450 BeadChip is a …

Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array

H Naeem, NC Wong, Z Chatterton, MKH Hong… - BMC genomics, 2014 - Springer
Abstract Background The Illumina HumanMethylation450 BeadChip (HM450K) measures
the DNA methylation of 485,512 CpGs in the human genome. The technology relies on …