Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-
cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides …

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing.
Recently, it has become increasingly clear that both correct levels and proper interpretation …

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several
neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the …

The Rett-syndrome-associated methyl-CpG-binding protein 2 (MeCP2) selectively binds
methylated DNA to regulate transcription during the development of mature neurons. Like …

The methyl-CpG-binding protein MeCP2 was discovered over 15 years ago as part of a
search for proteins that selectively bind methylated DNA. It is a nuclear protein that is largely …

Methyl-CpG binding protein 2 (MeCP2) was first identified in 1992 as a protein that binds
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …

Methylation of DNA is essential for development in the mouse and plays an important role in
inactivation of the X-chromosome, genomic imprinting and gene silencing. The properties of …

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional repressor which recognizes
methylated CpG dinucleotides. Mutations in the MeCP2 gene is known to cause human …

Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-
CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is …

DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of
which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to …