Interest in the involvement of cell proliferation in carcinogenesis is focusing on discerning
precisely the role or roles this phenomenon plays [l]. The specific aim of this communication …

The overall objective of our research is to discern mechanisms that can facilitate the
aberrant expression of oncogenes involved in carcinogenesis. We are testing the hypothesis …

There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC]
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …

DNA methylation (ie, the 5-methylcytosin content of DNA) plays a role in the regulation of
gene activity. There is a persuasive body of evidence indicating that differential methylation …

In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …

It is now generally accepted that the presence of 5-methylcytosine (5mC) in human DMA has
both a genetic and an epigenetic effect on cellular development, differentiation and …

It is not surprising that cancer, a kind of derangement of development, hijacks DNA
methylation, which is necessary for normal mammalian embryogenesis. Both decreases and …

We propose a general model for neoplastic development which postulates that the loss of
methyl groups from 5-methylcytosines (5-mC) involved in the control of gene expression …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

This review focuses on the role that DNA methylation plays in the regulation of normal and
aberrant gene expression and on how, in a hypothesis-driven fashion, altered DNA …