Major advances in the understanding of the genetics and pathogenesis of autosomal
dominant polycystic kidney disease have occurred within the past year. The proteins …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in at least
three different genes: PKD1, PKD2, and PKD3. ADPKD1 is an inherited disorder that has led …

Autosomal-dominant polycystic kidney disease results from at least two causal genes, PKD1
and PKD2. The identical clinical phenotype in human patients and targeted Pkd1 and Pkd2 …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common progressive
hereditary kidney disease. In 85–90% of cases, ADPKD results from a mutation in the PKD1 …

Considerable progress toward understanding pathogenesis of autosomal dominant
polycystic disease (ADPKD) has been made during the past 15 years. ADPKD is a …

Autosomal dominant polycystic kidney disease (ADPKD) is a major, inherited disorder that is
characterized by the growth of large, fluid-filled cysts from the tubules and collecting ducts of …

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited nephropathy,
usually of late onset (onset between third to seventh decade), primarily characterized by the …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutation of one of two
genes: PKD1 (16p13. 3) or PKD2 (4q13–23). PKD1 accounts for∼ 85% of pedigrees and is …

The identification of PKD1 and PKD2, the two major genes responsible for autosomal
dominant polycystic kidney disease, are the seminal discoveries upon which much of the …

Polycystic kidney disease (PKD) is a major, multigene disorder that is characterized by the
growth of large, fluid-filled cysts from the nephrons and collecting ducts of affected kidneys …