Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli
The calibration of functional magnetic resonance imaging (fMRI) for the estimation of
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
Sources of systematic bias in hypercapnia-calibrated functional MRI estimation of oxygen metabolism
The change in cerebral rate of oxidative metabolism (CMRO2) during neural activation may
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
Calibrated fMRI
RD Hoge - Neuroimage, 2012 - Elsevier
Functional magnetic resonance imaging with blood oxygenation level-dependent (BOLD)
contrast has had a tremendous influence on human neuroscience in the last twenty years …
contrast has had a tremendous influence on human neuroscience in the last twenty years …
[HTML][HTML] Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration
A Merola, K Murphy, AJ Stone, MA Germuska… - Neuroimage, 2016 - Elsevier
Several techniques have been proposed to estimate relative changes in cerebral metabolic
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging
RG Wise, KTS Pattinson, DP Bulte… - Journal of Cerebral …, 2007 - journals.sagepub.com
Investigations into the blood oxygenation level-dependent (BOLD) functional MRI signal
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …
Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation
EK Englund, MA Fernández-Seara… - Journal of Cerebral …, 2020 - journals.sagepub.com
Functional MRI (fMRI) can identify active foci in response to stimuli through BOLD signal
fluctuations, which represent a complex interplay between blood flow and cerebral …
fluctuations, which represent a complex interplay between blood flow and cerebral …
Searching for a truly “iso-metabolic” gas challenge in physiological MRI
Hypercapnia challenge (eg inhalation of CO2) has been used in calibrated fMRI as well as
in the mapping of vascular reactivity in cerebrovascular diseases. An important assumption …
in the mapping of vascular reactivity in cerebrovascular diseases. An important assumption …
A calibration method for quantitative BOLD fMRI based on hyperoxia
The estimation of changes in CMRO2 using functional MRI involves an essential calibration
step using a vasoactive agent to induce an isometabolic change in CBF. This calibration …
step using a vasoactive agent to induce an isometabolic change in CBF. This calibration …