Autoimmune diseases are a broad spectrum of disorders involved in the imbalance of T-cell
subsets, in which interplay or interaction of Th1, Th17 and Tregs are most important …

Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders.
Over the years, it has become clear that melatonin may exacerbate some autoimmune …

Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

Melatonin is the major secretory product of the pineal gland during the night and has
multiple activities including the regulation of circadian and seasonal rhythms, and …

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the
production of antinuclear autoantibodies. In addition, the involvement of CD 4+ T‐helper …

The hormone melatonin has many properties, including antioxidant, anti‐inflammatory, and
immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several …

Toll‐like receptors (TLRs) are crucial activators of inflammatory responses, they are
considered immune receptors. TLRs are of fundamental importance in the pathophysiology …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

An association of melatonin levels with age disease initiation of autoimmune diseases and
pineal calcification was reported while an inverse association between melatonin levels and …