Does melatonin play a disease-promoting role in rheumatoid arthritis?
The pineal neurohormone melatonin (MLT) has been widely shown to exert an
immunostimulatory and antiapoptotic role, mainly by acting on Th cells and on T and B cell …
immunostimulatory and antiapoptotic role, mainly by acting on Th cells and on T and B cell …
Can melatonin reduce the severity of COVID-19 pandemic?
A Shneider, A Kudriavtsev… - International reviews of …, 2020 - Taylor & Francis
The current COVID-19 pandemic is one of the most devastating events in recent history. The
virus causes relatively minor damage to young, healthy populations, imposing life …
virus causes relatively minor damage to young, healthy populations, imposing life …
Blocking of melatonin synthesis and MT1 receptor impairs the activation of Jurkat T cells
PJ Lardone, A Rubio, I Cerrillo… - Cellular and molecular …, 2010 - Springer
Melatonin has been proposed as regulating the immune system by affecting cytokine
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …
Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis
J Huang, Z Li, Y Hu, Z Li, Y Xie, H Huang… - Journal of …, 2022 - Springer
Background Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in
maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti …
maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti …
The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review
C Pivonello, M Negri, R Patalano, F Amatrudo… - Obesity …, 2022 - Wiley Online Library
Obesity is a chronic condition whose management is a critical challenge for physicians. The
scientific community has increased its focus on the molecular mechanisms involved in …
scientific community has increased its focus on the molecular mechanisms involved in …
The role of melatonin in Multiple Sclerosis
C Skarlis, M Anagnostouli - Neurological Sciences, 2020 - Springer
Melatonin is a neurohormone mainly produced by the pineal gland following a circadian
rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake …
rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake …
Melatonin: a pleiotropic molecule regulating inflammation
Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …
[HTML][HTML] Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice
J Luo, Z Zhang, H Sun, J Song, X Chen, J Huang, X Lin… - Life sciences, 2020 - Elsevier
Melatonin is an indole neuroendocrine hormone that is mainly secreted by the pineal gland
to regulate circadian rhythm, antioxidation, and immune regulation. Melatonin plays an …
to regulate circadian rhythm, antioxidation, and immune regulation. Melatonin plays an …
Melatonin as an anti‐inflammatory agent modulating inflammasome activation
G Favero, L Franceschetti, F Bonomini… - International journal …, 2017 - Wiley Online Library
Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …
Melatonin and health: insights of melatonin action, biological functions, and associated disorders
Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …
living organisms. In human beings, pineal gland is the major site for melatonin production …