Does melatonin play a disease-promoting role in rheumatoid arthritis?

GJM Maestroni, DP Cardinali, AI Esquifino… - Journal of …, 2005 - Elsevier
The pineal neurohormone melatonin (MLT) has been widely shown to exert an
immunostimulatory and antiapoptotic role, mainly by acting on Th cells and on T and B cell …

Can melatonin reduce the severity of COVID-19 pandemic?

A Shneider, A Kudriavtsev… - International reviews of …, 2020 - Taylor & Francis
The current COVID-19 pandemic is one of the most devastating events in recent history. The
virus causes relatively minor damage to young, healthy populations, imposing life …

Blocking of melatonin synthesis and MT1 receptor impairs the activation of Jurkat T cells

PJ Lardone, A Rubio, I Cerrillo… - Cellular and molecular …, 2010 - Springer
Melatonin has been proposed as regulating the immune system by affecting cytokine
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …

Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis

J Huang, Z Li, Y Hu, Z Li, Y Xie, H Huang… - Journal of …, 2022 - Springer
Background Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in
maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti …

The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review

C Pivonello, M Negri, R Patalano, F Amatrudo… - Obesity …, 2022 - Wiley Online Library
Obesity is a chronic condition whose management is a critical challenge for physicians. The
scientific community has increased its focus on the molecular mechanisms involved in …

The role of melatonin in Multiple Sclerosis

C Skarlis, M Anagnostouli - Neurological Sciences, 2020 - Springer
Melatonin is a neurohormone mainly produced by the pineal gland following a circadian
rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake …

Melatonin: a pleiotropic molecule regulating inflammation

F Radogna, M Diederich, L Ghibelli - Biochemical pharmacology, 2010 - Elsevier
Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

[HTML][HTML] Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice

J Luo, Z Zhang, H Sun, J Song, X Chen, J Huang, X Lin… - Life sciences, 2020 - Elsevier
Melatonin is an indole neuroendocrine hormone that is mainly secreted by the pineal gland
to regulate circadian rhythm, antioxidation, and immune regulation. Melatonin plays an …

Melatonin as an anti‐inflammatory agent modulating inflammasome activation

G Favero, L Franceschetti, F Bonomini… - International journal …, 2017 - Wiley Online Library
Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …

Melatonin and health: insights of melatonin action, biological functions, and associated disorders

SB Ahmad, A Ali, M Bilal, SM Rashid, AB Wani… - Cellular and Molecular …, 2023 - Springer
Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …