Melatonin is well known for its circadian production by the pineal gland, and there is a
growing body of data showing that it is also produced by many other cells and organs …

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …

Physical or psychological stress can cause an immunologic imbalance that disturbs the
central nervous system followed by neuroinflammation. The association between …

The de novo generation of Foxp3+ regulatory T (Treg) cells in the peripheral immune
compartment and the differentiation of Th17 cells both require TGF-β, and IL-6 and IL-21 are …

Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

Autoimmune diseases (ADs) are a heterogeneous groups of diseases that occur as a results
of loss of tolerance to self antigens. While the etiopathogeneis remain obscure, different …

Background NLRP3 inflammasome activation plays a critical role in mediating inflammation
and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Melatonin is an indoleamine with potent multifunctional biological and pharmacological
effects, both receptor dependent and receptor-independent effects, including antioxidant …

NLRP3 inflammasome is a part of the innate immune system and responsible for the rapid
identification and eradication of pathogenic microbes, metabolic stress products, reactive …