A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …

Physical or psychological stress can cause an immunologic imbalance that disturbs the
central nervous system followed by neuroinflammation. The association between …

The zebrafish has become an excellent model for the study of human diseases because it
offers many advantages over other vertebrate animal models. The pineal gland, as well as …

The de novo generation of Foxp3+ regulatory T (Treg) cells in the peripheral immune
compartment and the differentiation of Th17 cells both require TGF-β, and IL-6 and IL-21 are …

Background NLRP3 inflammasome activation plays a critical role in mediating inflammation
and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and …

Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Melatonin is an indoleamine with potent multifunctional biological and pharmacological
effects, both receptor dependent and receptor-independent effects, including antioxidant …

We determined the NF‐κB‐and NOD‐like receptor (NLR) P3‐dependent molecular
mechanisms involved in sepsis and evaluated the role of retinoid‐related orphan receptor …

The last four decades, we assist to an increasing scientific interest on melatonin, a circadian
hormone, a metabolic regulator which influences not only plants' metabolism and their …