Melatonin and health: insights of melatonin action, biological functions, and associated disorders

SB Ahmad, A Ali, M Bilal, SM Rashid, AB Wani… - Cellular and Molecular …, 2023 - Springer
Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Melatonin and related compounds: antioxidant and anti-inflammatory actions

M Bantounou, J Plascevic, HF Galley - Antioxidants, 2022 - mdpi.com
Melatonin, an indoleamine derived from tryptophan and produced in the pineal gland and
other tissues [1, 2] is a potent antioxidant and inflammatory agent [1]. Specifically, the …

Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review

M Imenshahidi, G Karimi, H Hosseinzadeh - … -Schmiedeberg's Archives of …, 2020 - Springer
Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland.
Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator …

Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment

VMM Giménez, F Inserra, CD Tajer, J Mariani, L Ferder… - Life sciences, 2020 - Elsevier
COVID-19 pandemic has a high mortality rate and is affecting practically the entire world
population. The leading cause of death is severe acute respiratory syndrome as a …

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining …

C Luo, Q Yang, Y Liu, S Zhou, J Jiang, RJ Reiter… - Free Radical Biology …, 2019 - Elsevier
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly
produced by the pineal gland. Numerous physiological functions of melatonin have been …

Cardiovascular benefits of dietary melatonin: a myth or a reality?

Z Jiki, S Lecour, F Nduhirabandi - Frontiers in physiology, 2018 - frontiersin.org
The role of the diet as well as the impact of the dietary habits on human health and disease
is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well …

Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases

VM Martín Giménez, N de Las Heras… - Frontiers in Aging …, 2022 - frontiersin.org
The concept of “aging” is defined as the set of gradual and progressive changes in an
organism that leads to an increased risk of weakness, disease, and death. This process may …

The oxidant/antioxidant network: role of melatonin

RJ Reiter, DX Tan, J Cabrera, D D'Arpa, RM Sainz… - Neurosignals, 1999 - karger.com
Melatonin is now known to be a multifaceted free radical scavenger and antioxidant. It
detoxifies a variety of free radicals and reactive oxygen intermediates including the hydroxyl …

Melatonin in relation to physiology in adult humans: Mini Review

A Cagnacci - Journal of pineal research, 1996 - Wiley Online Library
The role exerted by melatonin in human physiology has not been completely ascertained.
Melatonin levels have been measured in different physiopathological conditions, but the …

Melatonin: Protection against age-related cardiac pathology

G Favero, L Franceschetti, B Buffoli… - Ageing research …, 2017 - Elsevier
Aging is a complex and progressive process that involves physiological and metabolic
deterioration in every organ and system. Cardiovascular diseases are one of the most …