Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …

Over three centuries ago, the French philosopher René Descartes described the pineal
gland as “the seat of the soul.” However, it was not until the late 1950s that the chemical …

Autoimmune diseases are a broad spectrum of disorders involved in the imbalance of T-cell
subsets, in which interplay or interaction of Th1, Th17 and Tregs are most important …

Melatonin is a widespread molecule among living organisms involved in multiple biological,
hormonal, and physiological processes at cellular, tissue, and organic levels. It is well …

Melatonin is an uncommonly widely distributed molecule. It is found throughout the plant
and animal kingdoms, ie, perhaps in every living organism. Within vertebrate organisms …

Melatonin is a versatile molecule, synthesized not only by the pineal gland, but also in small
amounts by many other organs like retina, gastrointestinal tract, thymus, bone marrow …

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …

Melatonin is a small, highly conserved indole with numerous receptor-mediated and
receptor-independent actions. Receptor-dependent functions include circadian rhythm …

Diseases caused by pathogenic bacteria in animals (eg, bacterial pneumonia, meningitis
and sepsis) and plants (eg, bacterial wilt, angular spot and canker) lead to high prevalence …