The tumor immune microenvironment (TIME), an immunosuppressive niche, plays a pivotal
role in contributing to the development, progression, and immune escape of various types of …

The tumor immune microenvironment represents a sophisticated ecosystem where various
immune cell subtypes communicate with cancer cells and stromal cells. The dynamic …

Epigenetic regulation of gene expression in cancer cells has been extensively studied in
recent decades, resulting in the FDA approval of multiple epigenetic agents for treating …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Background Epigenetic alterations are known contributors to cancer development and
aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation,
angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA …

Chronic inflammation promotes tumor development, progression, and metastatic
dissemination and causes treatment resistance. The accumulation of genetic alterations and …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

The tumour microenvironment plays an instrumental role in cancer development,
progression and treatment response/resistance. Accumulating evidence is underscoring the …